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Dictionary of Evidenced-Based Ingredients

Don’t just take any supplement and not know exactly what you're putting into your body. Be revolutionary with your health, fitness, and supplement regimen. We provide you with the knowledge to know what’s in our supplements and exactly what they are designed to do for your body, health, and fitness.

 

BACOPA MONNIERI (LEAF)

What is it?
Bacopa monnieri is a nootropic herb that has been used in traditional medicine for longevity and cognitive enhancement. Supplementation can reduce anxiety and improve memory.

What does it do?
Bacopa monnieri interacts with the dopamine and serotonergic systems, but its main mechanism concerns promoting neuron communication. It does this by enhancing the rate at which the nervous system can communicate by increasing the growth of nerve endings, called dendrites. Bacopa monnieri is also an antioxidant. 

BETA-ALANINE

What is it?
Beta-alanine is the building block of carnosine, a molecule that helps buffer acid in muscles, increasing physical performance in the range of 60-240 seconds. Beta-alanine can aid lean-mass gain. Carnosine appears to be an antioxidant and anti-aging compound.

What does it do?
Beta-alanine has been shown to enhance muscular endurance. Beta-alanine supplementation can also improve moderate- to high-intensity cardiovascular exercise performance, like rowing or sprinting. 

BETAINE ANHYDROUS

What is it?
Betaine Anhydrous is a compound that the body uses to breakdown harmful substances.

What does it do?
It has been used to promote liver health and improve athletic performance. 

BIOPERINE (BLACK PEPPER EXTRACT)

What is it?
Bioperine is a branded extract of black pepper and is 95% piperine. Black Pepper is a source of piperine, a molecule that does not do much on its own but can inhibit enzymes that would attack other molecules. Due to this, it is ingested alongside some supplements to increase their absorption rates.

What does it do?
It can enhance the absorption or bioavailability of certain compounds, such as curcumin from turmeric. 

CAFFEINE

What is it?
Caffeine is a stimulatory anti-sleep compound extracted from coffee beans. It is often the main ingredient for pre-workout supplements or energy drinks. Habitual caffeine use leads to tolerance, which dulls several of caffeine’s effects.

What does it do?
Caffeine inhibits adenosine receptors. Adenosine causes a feeling of relaxation and sleepiness when it acts on brain receptors. Caffeine prevents this action and causes alertness and wakefulness. This inhibition of adenosine can influence the dopamine, serotonin, acetylcholine, and adrenaline systems. Caffeine is a powerful stimulant, and it can be used to improve physical strength and endurance. It is classified as a nootropic because it sensitizes neurons and provides mental stimulation. 

 

CAFFEINE ANHYDROUS

What is it?
Caffeine Anhydrous is a highly concentrated caffeine powder that is made from the seeds and leaves of coffee plants.

What does it do?
Caffeine Anhydrous is used to stimulate athletic performance or weight loss. 

CREATINE MONOHYDRATE

What is it?
Creatine is a molecule that's produced in the body from amino acids. It's primarily made in the liver and, to a lesser extent, in the kidneys and pancreas. It stores high-energy phosphate groups in the form of phosphocreatine, which are donated to ADP and regenerates it to ATP, the primary energy carrier in the body. This role in energy production is particularly relevant under conditions of high energy demand such as intense physical or mental activity.

What does it do?
Creatine can help with exercise performance by rapidly producing energy during intense activity. The primary benefit of creatine is an improvement in strength and power output during resistance exercise. When used in conjunction with resistance exercise, creatine may modestly increase lean mass. 

 

CHOLINE BITARTRATE

What is it?
Choline is a molecule mostly used for either its cognitive-boosting properties or as a liver health agent, able to reduce fatty liver buildup.

What does it do?
Choline supports various bodily functions, including cellular growth, metabolism, liver function, healthy brain development, muscle movement, and your nervous system. 

GAMMA-AMINOBUTYRIC ACID (GABA)

What is it?
GABA is the 'downer' neurotransmitter that counters glutamate (“upper”), as the two mediate brain activation in a ying yang manner. Highly important in the brain, oral ingestion of GABA is complex due to its difficulty in crossing the blood brain barrier.

What does it do?
GABA has been used to ease anxiety, stress, and problems with sleep. GABA has also been used to lower blood pressure 

DYNAMINE

What is it?
Dynamine is methylliberine, a purine alkaloid found in the kucha tea leaf. Its molecular structure is similar to theacrine (aka TeaCrine®) and is believed to behave in similar ways in the body.

What does it do?
Like theacrine, methylliberine may amplify feelings of energy, mood and focus by activating dopamine receptors and other key neurotransmitters, inhibiting adenosine receptors, all without elevating heart rate or blood pressure. 

DMAE BITARTRATE

What is it?
DMAE (2-Dimethylaminoethanol) is a compound that is known as a mind health compound - choline which has the ability to reduce build-up of the age pigmentation known as beta-amyloid.

What does it do?
It can protect neurons and other cells from harmful effects of certain types of oxidation by acting as an antioxidant as well as sustaining metabolic processes in the body through a process known as methyl donation.  

LION’S MANE

What is it?
Lion's Mane is known as Yamabushitake. It is a dietary mushroom that can be a supplement. It appears to be a promising cognitive enhancer and immunomodulator (supports the immune system).

What does it do?
It is responsible for the incredible brain enhancing benefits for memory, cognitive brain function, and improved mood. 

REISHI

What is it?
Reishi is known as Ganoderma lucidum and is a fungus that originated in Asian countries. Reishi is a mushroom that grows on trees. It has been used to improve heart and brain health. Reishi contains beta glucans, a type of fiber found in the cell walls of cereals, bacteria, and fungi. Beta glucans are taken by mouth for high cholesterol.

What does it do?
Limited data from clinical studies suggest reishi can strengthen immune response in humans. Resishi mushrooms also have substances known as triterpenes that may have blood pressure-lowering and anti-allergy effects. 

CORDYCEPS

What is it?
Cordyceps is a fungus that grows on the larvae of the caterpillar Hepialus armoricanus Oberthuer.

What does it do?
This fungus is known to improve energy levels through ATP production with increased oxygen utilization, which may enhance aerobic capacity and athletic endurance. It is used for a wide range of conditions including fatigue, sexual dysfunction, coughs, and as an adaptogen or immune stimulant.  

WHEY PROTEIN

What is it?

Whey and casein protein are both derived from milk. Whey protein powder is extremely popular due to its high digestibility and well-researched muscle-supporting benefits. Whey is most often a byproduct of cheesemaking. Whey’s dry mass is 75% carbs (lactose), 13% protein, and 1% fat. Whey protein is highly bioavailable and has an excellent amino acid profile. Whey protein is 52% essential amino acids and 13.6% leucine, whereas other animal-based proteins from foods are roughly 40–45% essential amino acids and 7–8% leucine, and plant-based proteins are even lower than that. 

What does it do?

It’s a high-quality, well-absorbed source of protein that’s very useful for hitting targeted daily protein goals. Its benefits extend to the benefits of increased protein intake in general, such as augmenting muscle gain in conjunction with resistance training, limiting muscle loss during low-calorie diets, and modestly limiting fat gain during periods of excessive calorie intake

Whey and casein protein are both derived from milk. Whey protein powder is extremely popular due to its high digestibility and well-researched muscle-supporting benefits. Whey is most often a byproduct of cheesemaking. Whey’s dry mass is 75% carbs (lactose), 13% protein, and 1% fat. Whey protein is highly bioavailable and has an excellent amino acid profile. Whey protein is 52% essential amino acids and 13.6% leucine, whereas other animal-based proteins from foods are roughly 40–45% essential amino acids and 7–8% leucine, and plant-based proteins are even lower than that. 

 

Vitamin B1



What is it?
Thiamine (Vitamin B1) is an essential vitamin involved heavily in glucose production.

What does it do?
Vitamin B1 has been used to improve heart health and ease digestion. It has also been used to manage thiamine deficiency.  

Vitamin B2



What is it?
Vitamin B2, also known as riboflavin, is an essential vitamin that is required for some enzymes in the body to act normally. It may serve some benefits for cardiovascular health in genetically susceptible people. Riboflavin produces two cofactors known flavoproteins, FAD and FMN. Some proteins in the body are dependent on these cofactors to help them function properly and optimally.

What does it do?
Riboflavin has been affiliated with reducing homocysteine levels (a marker for cardiovascular disease). Vitamin B2 has also been affiliated with reducing migraine frequency. Riboflavin is also needed to help support and facilitate energy metabolism and has implications for the antioxidant system of the body.

Vitamin B3



What is it?
Niacin is an essential B vitamin. Supplementation results in improved cholesterol and triglyceride levels. However, since a side effect of supplementation is increased insulin resistance, niacin supplementation only provides benefits for cardiovascular health if precautions are taken.

What does it do?
The body uses vitamin B3 to make energy from fats and carbs. Vitamin B3 has been used to improve heart health and lower cholesterol. It has also been used to improve symptoms of diabetes.

Vitamin B5



What is it?
Pantothenic acid is one of the B vitamins that is critical in the formation of co-enzyme A, a molecule which helps a large amount of enzymes function in the body and for energy production in general. Found in most food groups; chicken, beef, egg yolk, and organs are high sources for animal products, while root vegetables such as potatoes, whole grains, tomatoes, and broccoli are plant sources that also have a large level of pantothenic acid.

What does it do?
The body uses vitamin B5 to break down carbs and fats. Pantothenic acid has been used to promote heart and liver health. It has also been used to lower cholesterol and ease swelling in the joints. As a precursor to co-enzyme A, it is required in approximately 4% of all known enzymes as a cofactor, mostly known for being involved in energy production.  

VITAMIN B6

What is it?

Vitamin B6, also known as pyridoxine, is one of the water-soluble B vitamins and is used in producing coenzymes in the body. It is a mixture of six inter-convertible pyridine vitamins or related compounds. Plants and microorganisms can synthesize B6; however humans must acquire B6 from the diet. Vitamin B6 is abundant in meats, fish, poultry, shellfish, leafy green vegetables, legumes, fruits, and whole grains.

What does it do?
Vitamin B6, pyridoxine, is important for normal brain development and for keeping the nervous system and immune system healthy. It is used to treat a certain type of anemia, specifically the lack of red blood cells. Vitamin B6 also is necessary to support cellular respiration, release of glucose stores, and amino acid metabolism.  

VITAMIN B12

What is it?

Vitamin B12, also known as cobalamin or cyanocobalamin, is a water-soluble vitamin known to play roles in neurology. Vitamin B12 is found in meat, fish, dairy products, and fortified cereals. Since vitamin B12 is found in many foods, deficiency is more common in the elderly, strict vegetarians, those who take oral contraceptives, or those taking medications for gastric disorders or insulin resistance.

What does it do?
Vitamin B12 is used as a cofactor for enzymes that support DNA synthesis and energy metabolism. Vitamin B12 is involved in the synthesis of phospholipids, neurotransmitters, and the metabolism of fatty acids and amino acids in cells.   

VITAMIN C

What is it?

Vitamin C is a water-soluble vitamin found in many fresh fruits and vegetables. It is essential for a variety of physiologic functions, including formation of collagen and catecholamines.

What does it do?
Oral vitamin C is consumed as an antioxidant supplement for immune protection against common colds and the flu. 

L-CITRULLINE MALATE

What is it?
L-Citrulline is an amino acid. It is efficiently turned into L-arginine in the kidneys after supplementation, which makes it a good choice for increasing nitric oxide synthesis in the body.

What does it do?
Research suggests a modest reduction in blood pressure and improvement in blood flow from chronic citrulline supplementation, particularly for those with hypertension and other cardiovascular problems. 

 

L-GLUTAMINE

What is it?

Glutamine is a conditionally essential amino acid and the most abundant amino acid in the human body. Glutamine can be found inherently in whey protein, wheat, corn, barley, peanuts, soybeans, and milk.

What does it do?
Glutamine is important for several bodily functions, and it is one of the building blocks for protein. Under conditions of stress, such as strenuous exercise or during illness, more glutamine may be needed to help restore glutamine levels in the body. Glutamine is also a major fuel source for the GI tract and helps support immune cells in the body for defense.  

L-THEANINE

What is it?

L-theanine is a water-soluble amino acid found in green tea.

What does it do?

L-theanine is used as an antioxidant and relaxant without drowsiness. It may help to reduce the perception of stress and slightly improve attention. L-theanine may also help to reduce the edginess of many stimulants.   

N-ACETYL L-TYROSINE (NALT)

What is it?

An acetylated form of the amino acid L-tyrosine. It is best soluble in water.

What does it do?

NALT is used as a nootropic because it acts as a precursor for the neurotransmitter dopamine. It helps to support working memory, logical reasoning, processing, and creativity.  

LEUCINE

What is it?
Leucine is an essential branched-chain amino acid and the most important amino acid for stimulating muscle protein synthesis in the body to help build muscle.

What does it do?
Leucine activates the mammalian target of Rapamycin to stimulate the process of muscle building.  

ISOLEUCINE

What is it?
Isoleucine is one of the three branched-chain amino acids and appears to promote glucose consumption and uptake.

What does it do?
Isoleucine is able to significantly increase glucose uptake and the usage of glucose during exercise. It also has the ability to induce protein muscle synthesis. 

VALINE

What is it?
Valine is one of the three branched-amino acids.

What does it do?
Valine can induce protein muscle synthesis. 

SOY LECITHIN

What it is?
Soy lecithin was first identified in egg yolks. Lecithin can be found in every cell in your body. Soy generally has negative perceptions but most are false, including the idea that soy decreases testosterone and interferes with thyroid function.

What does it do?
Soy lecithin is a natural emulsifier that helps the whey protein dissolve in liquids 

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